Advances in Wound Care and regenerative Medicine in Cutaneous Wound Healing

 Cutaneous wound healing has long been a magnet for tissue engineering and regenerative medicine due, in part, to the accessibility of skin, its flat structure and relatively avascular composition, and the fundamentally regenerative nature of healing. Cell therapies are already used for wounds, and good limb salvage options are lacking, rendering wound healing an attractive option for regenerative strategies. The field has witnessed pioneering efforts in tissue-engineered, cell-based, gene-based, and growth factor therapies. As per earlier definitions, to date, none of the commercially available products can truly be considered regenerative as none leads to the regeneration of adnexal structures of the skin such as hair follicles and sweat glands. Nevertheless, some of the tissue-engineered/regenerative medicine technologies have made valuable contributions to the field as demonstrated by significantly improved healing rates over standard of care in randomized trials. Thus, the field is evolving toward regenerative medicine even as most of the current tissue-engineered/regenerative medicine technologies are more in line with Yannas' characterization of partial regeneration.


  • Burns and scars
  • Burns and schleroderma
  • Peripheral arterial disease and diabetic foot ulcers
  • Diabetic foot ulcers and venous leg ulcers
  • Diabetic foot ulcers and venous leg ulcers
  • Epidermolysis bullosa
  • Venous ulcers

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